Deficiência múltipla hipotálamo-hipofisária: defeito no gene "Prophet of Pit-1" (Prop-1)

Identification and analysis of prophet of Pit-1-binding sites in human Pit-1 gene.

Prophet of Pit-1 (Prop1) is a transcription factor that regulates Pit-1 gene expression. Because Pit-1 regulates the differentiation of pituitary cells and the expressions of GH, prolactin and TSHbeta genes, Prop1 mutation results in combined pituitary hormone deficiency in humans. However, Prop1-binding sites in human Pit-1 gene and the mechanism leading to combined pituitary hormone deficienc...

Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans.

Prophet of Pit-1 (Prop-1), which is a paired-like homeodomain transcription factor, is capable of binding to sites in an early enhancer of the Pit-1 gene and regulating its expression. According to a previous report, Prop-1 messenger RNA (mRNA) is expressed in the developing pituitary gland before Pit-1 mRNA expression and maximum expression are observed at e 12.0. After e 14.5, Prop-1 mRNA exp...

A new step understood in the cascade of tissue-specific regulators orchestrating pituitary lineage determination: the Prophet of Pit-1 (Prop-1).

An early step in generating specific cell types in embryos involves the commitment of multipotent stem cells to specific lineages. The anterior pituitary gland, with its five cell types originating from a common precursor, provides an instructive model to approach the mechanisms that control mammalian organ development and cell differentiation. Using the well-known model of the Ames dwarf mouse...

Synthesis of 1-Hydroxy-2-(Prop-2'-Enyl) 9-Antrone

An efficient synthesis of the 1-hydroxy-2-(prop-2'-enyl)9-anthrone is described. Selective nitration of anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-9,10-anthraquinone in good yield as the key intermediate. Reaction with allyl bromide/K2CO3 and subsequent selective reduction accompanie...

Persian-translation Vol.1, No.1